Science - January 21 2005.pdf - Science 2005 FULL - incestor

21 January 2005

Vol. 307 No. 5708

Pages 301–464

Vol. 307 No. 5708

Pages 301–464

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S PECIAL I SSUE

T YPE 2 D IABETES

Polarized light micrograph of glucose, the body’s major source of energy. In diabetes, glucose

is not properly metabolized and accumulates to dangerously high levels in the blood.

A special section in this issue examines the molecular pathogenesis of the most common

form of diabetes (type 2), which is projected to soon reach epidemic proportions worldwide.

[Image: Eye of Science/Photo Researchers Inc.]

Volume 307

21 January 2005

Number 5708

I NTRODUCTION

369 A Surfeit of Suspects

V IEWPOINTS

370

384 Mitochondrial Dysfunction and Type 2 Diabetes

B. B. Lowell and G. I. Shulman

Related Editorial page 317 ; News story page 334; Perspective page 366 ;

Reports pages 418 and 426

Genetic Factors in Type 2 Diabetes: The End of the

Beginning?

S. O’Rahilly, I. Barroso, N. J. Wareham

373

How Obesity Causes Diabetes: Not a Tall Tale

M. A. Lazar

For related online content,

see page 311 or go to

www.sciencemag.org/sciext/diabetes

375

Diabetes, Obesity, and the Brain

M. W. Schwartz and D. Porte Jr.

380

Type 2 Diabetes—a Matter of

-Cell Life and Death?

C. J. Rhodes

D EPARTMENTS

N EWS F OCUS

311

S CIENCE O NLINE

338

O CEANOGRAPHY

Grim Forecast for a Fading Fleet

313

T HIS W EEK IN S CIENCE

317

E DITORIAL by Derek Yach, Stephen R. Leeder,

John Bell, Barry Kistnasamy

Global Chronic Diseases

related Type 2 Diabetes section page 369

340

P ROFILE :F RED K AV L I

A New Benefactor Takes Aim at

Basic Scientific Questions

A Physics Home Away From Home

319

E DITORS ’C HOICE

324

C ONTACT S CIENCE

343

P ARASITOLOGY

Twisted Parasites From “Outer Space”

Perplex Biologists

329

N ET W ATCH

439

N EW P RODUCTS

440

S CIENCE C AREERS

345

I NDIAN O CEAN T SUNAMI

Using Scientific Assessments to Stave

Off Epidemics

N EWS OF THE W EEK

330

P LANETARY S CIENCE

Titan, Once a World Apart, Becomes

Eerily Familiar

346

M EETING

Society for Integrative and Comparative Biology

Scurrying Roaches Outwit Without Their Brains

With Flippers, Two Can Equal Four

More Than One Way to Dig a Tunnel

334 &

418

331

D ISASTER P REPAREDNESS

Global Tsunami Warning System Takes Shape

333

R ESEARCH P OLICY

Facing a Revolt, Pasteur Board Members

Offer to Resign

349

R ANDOM S AMPLES

L ETTERS

333

S CIENCE S COPE

353

Revisiting the Taxonomic Impediment M. R. de Carvalho

et al . A Clue to the Origin of the Bilateria? R. M. Rieger

et al . Response M. Q. Martindale and J. R. Finnerty

334

M EDICINE

Low-Power Mitochondria May

Raise Risk of Cardiovascular

Problems

related Type 2 Diabetes section page 369 ;

Report page 418

355

Corrections and Clarifications

B OOKS ET AL .

334

T EACHING E VOLUTION

Judge Orders Stickers Removed

From Georgia Textbooks

356

H ISTORY OF M EDICINE

Locating Medical History The Stories and

Their Meanings

F. Huisman and J. H. Warner, Eds., reviewed by X. Bosch

335

P ALEONTOLOGY

Fossil Count Suggests Biggest

Die-Off Wasn’t Due to a Smashup

356

P OLICY F ORUM

337

P ATENT L AW

Inventor Knocks Japan’s System

After Settlement

Shuji Nakamura Speaks Out

357

P UBLIC H EALTH

Cutting World Hunger in Half

P. A. Sanchez andM. S. Swaminathan

Contents continued

305

www.sciencemag.org

SCIENCE

VOL 307

21 JANUARY 2005

Science - January 21 2005.pdf

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