Accounts in Drug Discovery. Case Studies in Medicinal Chemistry.pdf

Accounts in Drug Discovery

Case Studies in Medicinal Chemistry

RSC Drug Discovery Series

Editor-in-Chief

Professor David Thurston, London School of Pharmacy, UK

Series Editors:

Dr David Fox, Pﬁzer Global Research and Development, Sandwich, UK

Professor Salvatore Guccione, University of Catania, Italy

Professor Ana Martinez, Instituto de Quimica Medica-CSIC, Spain

Dr David Rotella, Wyeth Research, USA

Advisor to the Board:

Professor Robin Ganellin, University College London, UK

Titles in the Series:

1: Metabolism, Pharmacokinetics and Toxicity of Functional Groups: Impact

of Chemical Building Blocks on ADMET

2: Emerging Drugs and Targets for Alzheimer’s Disease; Volume 1:

Beta-Amyloid, Tau Protein and Glucose Metabolism

3: Emerging Drugs and Targets for Alzheimer’s Disease; Volume 2: Neuronal

Plasticity, Neuronal Protection and Other Miscellaneous Strategies

4: Accounts in Drug Discovery: Case Studies in Medicinal Chemistry

How to obtain future titles on publication:

A standing order plan is available for this series. A standing order will bring

delivery of each new volume immediately on publication.

For further information please contact:

Book Sales Department, Royal Society of Chemistry, Thomas Graham House,

Science Park, Milton Road, Cambridge, CB4 0WF, UK

Telephone: +44 (0)1223 420066, Fax: +44 (0)1223 420247,

Email: books@ rsc.org

Visit our website at http://www.rsc.org/Shop/Books/

Accounts in Drug Discovery

Case Studies in Medicinal Chemistry

Edited by

Joel C. Barrish

Bristol-Myers Squibb, Princeton, NJ , USA

Percy H. Carter

Bristol-Myers Squibb, Princeton, NJ , USA

Peter T. W. Cheng

Bristol-Myers Squibb, Pennington, NJ, USA

Robert Zahler

PharmD Consulting, LLC, Pennington, NJ, USA

RSC Drug Discovery Series No. 4

ISBN: 978-1-84973-126-3

ISSN: 2041-3203

A catalogue record for this book is available from the British Library

r Royal Society of Chemistry 2011

Apart from fair dealing for the purposes of research for non-commercial purposes or for

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Act 1988 and the Copyright and Related Rights Regulations 2003, this publication may not

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The RSC is not responsible for individual opinions expressed in this work.

Published by The Royal Society of Chemistry,

Thomas Graham House, Science Park, Milton Road,

Cambridge CB4 0WF, UK

Registered Charity Number 207890

For further information see our web site at www.rsc.org

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