Antibiotics as Anti-Inflammatory and Immunomodulatory Agents.pdf

Progress in Inflammation Research

Series Editor

Prof. Michael J. Parnham PhD

Senior Scientific Advisor

PLIVA Research Institute Ltd.

Prilaz baruna Filipovi´a 29

HR-10000 Zagreb

Croatia

Advisory Board

G. Z. Feuerstein (Merck Research Laboratories, West Point, PA, USA)

M. Pairet (Boehringer Ingelheim Pharma KG, Biberach a. d. Riss, Germany)

W. van Eden (Universiteit Utrecht, Utrecht, The Netherlands)

Forthcoming titles:

Antirheumatic Therapy: Actions and Outcomes ,

R.O. Day, D.E. Furst, P.L. van Riel, B. Bresnihan (Editors), 2005

NPY Family of Peptides in Immune Disorders, Inflammation, Angiogenesis and Cancer ,

G.Z. Feuerstein, Z. Zukowska (Editors), 2005

Turning up the Heat on Pain: Vanilloid Receptors in Pain and Inflammation ,

A.B Malmberg, K.R. Bley (Editors), 2005

Regulatory T-Cells in Inflammation , L. Taams, A.N. Akbar, M.H.M. Wauben (Editors), 2005

Sodium Channels, Pain, and Analgesia , K. Coward, M. Baker (Editors), 2005

Complement and Kidney Disease , P.F. Zipfel (Editor), 2005

(Already published titles see last page.)

Antibiotics as Anti-Inflammatory and

Immunomodulatory Agents

Bruce K. Rubin

Jun Tamaoki

Editors

Birkhäuser Verlag

Basel · Boston · Berlin

Editors

Jun Tamaoki

First Department of Medicine

Tokyo Women`s Medical University

8-1 Kawada-Cho, Shinjuku

Tokyo 162-8666

Japan

Bruce K. Rubin

Department of Pediatrics

School of Medicine

Wake Forest University

Medical Center Boulevard

Winston-Salem, NC 27157-1081

USA

A CIP catalogue record for this book is available from the Library of Congress, Washington D.C., USA

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case.

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they are exempt from the relevant protective laws and regulations or free for general use.

ISBN 3-7643-5925-0 Birkhäuser Verlag, Basel – Boston – Berlin

This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned,

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Part of Springer Science+Business Media

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∞

Cover design: Markus Etterich, Basel

Cover illustration: Inhibitory effect of clarithromycin on LPS-induced MAC5AC gene expression and I-kappa-B-alpha

phosphorylation in human airway epithelial cells. With the friendly permission of Jun Tamaoki.

Printed in Germany

ISBN 3-7643-5925-0

9 8 7 6 5 4 3 2 1

www.birkhauser.ch

Contents

List of contributors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

vii

Preface . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

I. Basic research . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Indirect antimicrobial effects . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Kazuhiro Tateda, Theodore J. Standiford and Keizo Yamaguchi

Effects of antibiotics on Pseudomonas aeruginosa virulence factors

and quorum-sensing system . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Anti-inflammatory effects . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25

Michael J. Parnham

Antibiotics, inflammation and its resolution: an overview . . . . . . . . . . . . . . . . . . . . . . .

Charles Feldman and Ronald Anderson

The cytoprotective interactions of antibiotics with human ciliated

airway epithelium . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Jun-ichi Kadota

Chemotaxis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Hajime Takizawa

Cytokines . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Marie-Thérèse Labro

Antibacterial agents and the oxidative burst . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Jun-ichi Kadota

Immune system . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 107

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